发明名称 |
REVERSED MAMMALIAN PROTEIN-PROTEIN INTERACTION TRAP |
摘要 |
The present invention relates to a recombinant receptor, comprising a ligand - binding domain and a signaling domain that comprises a heterologous bait polypeptide, which receptor is inactivated by binding of a prey polypeptide to said heterologous bait peptide, either in presence or absence of a ligand binding to said ligand-binding domain. The receptor is activated by addition of a compound that disrupts the bait-prey interaction. The present invention also relates to a method to screen compounds that disrupt compound-compound- binding using said recombinant receptor.
|
申请公布号 |
CA2452353(A1) |
申请公布日期 |
2003.01.16 |
申请号 |
CA20022452353 |
申请日期 |
2002.07.02 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
EYCKERMAN, SVEN;VANDEKERCKHOVE, JOEL;TAVERNIER, JAN |
分类号 |
C07K14/47;C07K14/705;C12N15/10;(IPC1-7):C12N15/10 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|