The present invention discloses dye-azide derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture of Type 1 and Type 2 agents or a single entity that integrates both units in the same molecules. The compounds are designed to produce both Type 1 and Type 2 phototherapeutic effect at once using dual wavelength light source that will produce singlet oxygen and nitrene at the lesion of interest.
申请公布号
WO03003806(A2)
申请公布日期
2003.01.16
申请号
WO2002US19187
申请日期
2002.06.18
申请人
MALLINCKRODT, INC.;RAJAGOPALAN, RAGHAVAN;ACHILEFU, SAMUEL, I.;BUGAJ, JOSEPH, E.;DORSHOW, RICHARD, B.
发明人
RAJAGOPALAN, RAGHAVAN;ACHILEFU, SAMUEL, I.;BUGAJ, JOSEPH, E.;DORSHOW, RICHARD, B.