发明名称 |
DERIVADOS DE POLIAMIDA-OLIGONUCLEOTIDO, SU PREPARACION Y UTILIZACION. |
摘要 |
Polyamide-oligonucleotide derivatives (I) and their physiologically acceptable salts. Polyamide-oligonucleotide derivatives of formula F((DNA)-Li)q(PNA-Li)r(DNA-Li)s(PNA)t)xF' (I) and their physiologically acceptable salts are new. q, r, s, t = 0 or 1, with the sum of two or more adjacent letters at least 2; x = 1-20; DNA = nucleic acid (such as DNA or RNA or their known derivatives); Li = covalent linkage between DNA and PNA, i.e. a bond or a residue containing at least one atom of carbon, nitrogen, oxygen or sulfur; PNA = polyamide structure containing at least one nucleobase different from thymine; and F, F' = end groups and/or are connected through a covalent bond. Independent claims are also included for the following: (1) method for preparing (I); (2) pharmaceutical composition containing (I); and (3) gene probe assays for detecting oligo- or poly-nucleotide targets (RNA or DNA) in which (I) is used as probe and primer.
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申请公布号 |
ES2179080(T3) |
申请公布日期 |
2003.01.16 |
申请号 |
ES19950103332T |
申请日期 |
1995.03.08 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
UHLMANN, EUGEN, DR.;BREIPOHL, GERHARD, DR. |
分类号 |
C12N15/09;A61K47/48;C07H21/00;C07H21/04;C07K14/00;C08G69/10;C12Q1/68;(IPC1-7):C07H21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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