发明名称 |
METHOD FOR INDUCING ANALGESIA COMPRISING ADMINISTRATION ALTERNATIVELY OF AN OPIOID RECEPTOR AGONIST AND AN OPIOID RECEPTOR LIKE RECEPTOR 1 AGONIST FOR AND AN IMPLANTABLE INFUSION PUMP |
摘要 |
A method of producing analgesia in a mammal is provided by rotational (alternating) intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor agonist, such as a mu -, delta - or kappa -opioid receptor agonist for a first period of time, followed by intrathecal administration to the mammal of a pharmaceutically effective dose of at least one opioid receptor-like receptor 1 (ORL-1) agonist for a second period of time. The intrathecal drug administration of the first and second periods of time may be repeated a plurality of times without attaining tolerance in the mammal to either drug. Implantable apparatus for rotational administration of the active agents is also disclosed.
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申请公布号 |
WO03004034(A1) |
申请公布日期 |
2003.01.16 |
申请号 |
WO2002US06721 |
申请日期 |
2002.02.28 |
申请人 |
OMEROS CORPORATION;REGENTS OF THE UNIVERSITY OF CALIFORNIA;DEMOPULOS, GREGORY, A.;PALMER, PAMELA, PIERCE |
发明人 |
DEMOPULOS, GREGORY, A.;PALMER, PAMELA, PIERCE |
分类号 |
A61K45/06;A61K31/4436;A61K31/4439;A61K31/445;A61K31/4468;A61K31/4535;A61K31/485;A61K38/00;A61K38/07;A61K38/08;A61K38/10;A61M5/142;A61M5/168;A61M37/00;A61P25/04;A61P25/36;A61P43/00;(IPC1-7):A61K31/485;A61K31/446;A61K31/453;A61K31/454 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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