METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES

摘要

2'-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2'-O-(2-methoxyethyl)2'-O-MOE modification. The 2'-O-MOE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2'-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.