SENSOR AND METHOD FOR DETECTING REACTION OF SUBSTANCE USING THE SAME

摘要

PROBLEM TO BE SOLVED: To detect in real time a reaction of various substances such as antigen-antibody reaction or the like. SOLUTION: A sensor to be used for detecting a reaction of a first substance on a second substance has a substrate; first metal fine particles arranged respectively having a gap which does not mutually produce an interaction on the substrate; and a first substance coupled to the first metal fine particles. When second metal fine particles coupled to a second substance are supplied to the substrate, the first substance reacts on the second substance to couple to each other, with the result that the first metal fine particles are coupled to the second metal fine particles via the first substance and the second substance, to approach so that the first metal fine particles and the second metal fine particles produce mutually an interaction.