INCREASING ENANTIOSELECTIVITY IN REDUCTIONS WITH BORANE REAGENTS
摘要
A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species (for example, a borohydride stabilized borane-tetrahydrofuran complex) catalyzed by a chiral catalyst includes the step of maintaining the concentration of borohydride species in the borane reagent below approximately 0.005 M during the reduction of the prochiral substrate. A method of increasing enantioselectivity in a reduction reaction of a prochiral substrate with a borane reagent including a borohydride species that is catalyzed by a chiral catalyst includes the step of reducing the detrimental effect the borohydride species has on enantioselectivity by adding a Lewis acid. For example, the prochiral substrate can be a ketone and the chiral catalyst can be a chiral oxazaborolidine.
申请公布号
EP1274666(A1)
申请公布日期
2003.01.15
申请号
EP20010906624
申请日期
2001.01.22
申请人
MINE SAFETY APPLIANCES COMPANY
发明人
MATOS, KARL;CORELLA, JOSEPH, A., II;BURKHARDT, ELIZABETH, R.;NETTLES, SHAWN, M.