| 发明名称 |
Process to manufacture simvastatin and intermediates |
| 摘要 |
A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.
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| 申请公布号 |
US6506929(B1) |
申请公布日期 |
2003.01.14 |
| 申请号 |
US20010719606 |
申请日期 |
2001.04.24 |
| 申请人 |
APOTEX INC. |
发明人 |
KARIMIAN KHASHAYAR;TAM TIM FAT;TAO YONG;LI YIWEI;DOUCETTE GARY |
| 分类号 |
C07D309/10;C07D309/30;(IPC1-7):C07C69/74;C07C61/28 |
主分类号 |
C07D309/10 |
| 代理机构 |
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| 主权项 |
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