| 摘要 |
A novel 3-hydroxypyridin-4-one compound of formula I is providedwhereinR is hydrogen or a group that is removed by metabolism in vivo to provide the free hydroxy compound,R1 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group substituted by a hydroxy group or a carboxylic acid ester, sulpho acid ester or a C1-6 alkoxy, C6-aryloxy or C7-10aralkoxy ether thereof,R3 is selected from hydrogen and C1-6 alkyl;and R4 is selected from hydrogen, C1-6 alkyl and a group as described for R2;characterised in thatR2 is selected from groups(i) -CONH-R5(ii) -CH2NHCO-R5(iii) -SO2NH-R5(iv) -CH2NHSO2-R5(v) -CR6R6OR7(viii) -CONHCOR5 whereinR5 is selected from hydrogen and optionally hydroxy, alkoxy, or aralkoxy substituted C1-3 alkyl, aryl and C7-13 aralkyl,R6 is independently selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl,and R7 is selected from hydrogen, C1-13 alkyl, aryl and C7-13 aralkyl or a pharmaceutically acceptable salt of any such compoundwith the proviso that when R7 is hydrogen, R6 is not selected from aryl and with the proviso that the compound is not l-ethyl-2-(1'hydroxyethyl)-3-hydroxypyridin-4-one.
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