| 发明名称 |
Acetylenic alpha -amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| 摘要 |
Compounds of the formula: are useful in treating disease conditions mediated by TNF-alpha, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
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| 申请公布号 |
US2003008849(A1) |
申请公布日期 |
2003.01.09 |
| 申请号 |
US20000748912 |
申请日期 |
2000.12.27 |
| 申请人 |
LEVIN JEREMY I.;CHEN JAMES M.;COLE DEREK C.;DU MILA T.;LAAKSO LEIF M. |
发明人 |
LEVIN JEREMY I.;CHEN JAMES M.;COLE DEREK C.;DU MILA T.;LAAKSO LEIF M. |
| 分类号 |
A61K31/5375;A61K31/54;C07C311/29;C07D213/68;C07D279/10;C07D279/12;C07D309/12;C07F9/36;(IPC1-7):A61K31/665;A61K31/675;A61K31/55;C07F9/553 |
主分类号 |
A61K31/5375 |
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