PEPTIDES MIMICKING THE BIOLOGICAL ACTIVITY OF STEROID HORMONES AND THEIR USES

摘要

A monoclonal antibody to a steroid hormone is used for the isolation from a combinatorial peptide library of a peptide mimicking the biological activity of said steroid hormone. Peptides having estrogenic-like and progestational-like activity were synthesized and assayed for their ability to compete with the respective steroid hormone for binding to the monoclonal antibody and for binding to said steroid hormone receptor. Peptides having estrogenic-like activity were found to be selective to estrogen receptor alpha or beta and thus may have more clinical applications than the non-selective steroid hormone estradiol.