发明名称 |
Novel signaling pathway for the production of inflammatory pain and neuropathy |
摘要 |
This invention pertains to the discovery of a novel pathway that mediates hyperalgesia, neuropathic pain, and inflammatory pain. This pathway is a third independent pathway that involves activation of extracellular signal-regulated kinases (ERKs) 1 and 2. The pathway comprises a Ras-MEK-ERK1/2 cascade that acts independent of PKA or PKCepsi as a novel signaling pathway for the production of inflammatory (and neuropathic) pain. This pathway presents numerous targets for a new class of analgesic agents.
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申请公布号 |
US2003008807(A1) |
申请公布日期 |
2003.01.09 |
申请号 |
US20020173332 |
申请日期 |
2002.06.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
LEVINE JON DAVID;MESSING ROBERT O. |
分类号 |
A61K31/00;A61K38/16;A61K38/45;A61K45/06;C12Q1/48;G01N33/50;(IPC1-7):A61K31/00;G01N33/567 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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