NOVEL USE OF DITERPENE COMPOUNDS AS THERAPEUTIC AGENTS OF INFLAMMATION, IMMUNE DISEASE AND CANCER

摘要

PURPOSE: Provided is a novel use of diterpene compounds as therapeutic agents of inflammation, immune disease and cancer, particularly, the diterpene compounds includes kamebanin of the formula(1), kamebacetal A of the formula(2), kamebakaurin of the formula(3) and exisanin A of the formula(4) which have excellent anti-inflammatory and anti-cancer activities. CONSTITUTION: The diterpene compounds including kamebanin of the formula(1), kamebacetal A of the formula(2), kamebakaurin of the formula(3) and exisanin A of the formula(4) inhibit NF-kB which is a transcriptional factor in the expression of iNOS or COX-2. Especially kamebakaurin inhibits the expression of Bfl-1/A1, cIAP-1 and cIAP-2 which inhibit cell death. An inhibitor of expression of cell death inhibitory genes contains kamebanin, kamebacetal A, kamebakaurin and exisanin A, or their pharmaceutically acceptable salts as active ingredients.