PREPARATION OF IBUPROFEN ENANTIOMER

摘要

PURPOSE: Provided is a method of preparing pure S(+) enantiomer of Ibuprofen from the racemic mixture, which is harmless to the human and economical. The S(+) enantiomer has activity as anti-inflammatory agent while R(-) isomer is inactive. CONSTITUTION: The preparation method comprises: a step of adding N-octyl-D-glucamine to the mixed polar solvent of ethanol and 1-5% of water in which Ibuprofen is dissolved in a mole ratio of 0.9:1 - 0.95:1(based on the mole of the wanted enantiomer in Ibuprofen) to obtain N-octyl-D-glucamine salt of Ibuprofen with the wanted enantiomer structure and separating; a step of hydrolyzing N-octyl-D-glucamine from N-octyl-D-glucamine salt by adding NaOH solution and separating; a step of adding HCl to the remaining solution with no N-octyl-D-glucamine and extracting the organic layer from it by using N-heptane, and the final step of filtering the extract and drying to obtain the wanted enantiomer.