发明名称 UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE
摘要 The invention concerns novel products of formula (I) wherein: Y represents oxygen or sulphur; Z represents C=CH2, CH-CH3 or CH2; R1 represents hydrogen, morpholinyl or the radical (II) wherein the two nitrogen atoms are linear or form a cyclic radical; X represents carbonyl, alkylene or alkenylene, linear or branched containing not more than 6 carbon atoms optionally oxygen- or sulphur-interrupted; R4, R5 and R6 represent hydrogen, a nitrogen-protecting, alkyl, cycloalkyl, aryl and arylalkyl group optionally substituted; R2 represents alkyl optionally substituted by aryl, heteroaryl or -NR4R5; R3 represents alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl optionally substituted. Said products are all in the form of isomers and the salts as medicines.
申请公布号 WO02059102(A3) 申请公布日期 2003.01.09
申请号 WO2002FR00279 申请日期 2002.01.23
申请人 AVENTIS PHARMA S.A.;DEPREZ, PIERRE;PATEK, MARCEL 发明人 DEPREZ, PIERRE;PATEK, MARCEL
分类号 C07D243/08;A61K31/17;A61K31/175;A61K31/36;A61K31/495;A61K31/496;A61K31/551;A61P1/00;A61P3/14;A61P5/18;A61P9/00;A61P9/12;A61P19/00;A61P19/02;A61P19/08;A61P25/08;A61P25/22;A61P25/24;A61P25/28;A61P29/00;A61P31/00;A61P35/00;A61P37/00;C07C273/18;C07C275/24;C07C275/26;C07C275/28;C07C275/34;C07C275/42;C07D295/12;C07D295/13;C07D295/18;C07D317/58;C07D333/20;C07D407/12 主分类号 C07D243/08
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