ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES
摘要
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula (II) and enzymatically converting a compound of formula (II) to form a 3-thiolated-7-ACA of the formula (III) wherein R is a heterocyclic group comprising at least one nitrogen atom and R1 And R2 are both hydrogen atoms or one of them is a hydrogen atom and the other is an acyl donor.
申请公布号
WO02086143(A3)
申请公布日期
2003.01.09
申请号
WO2002EP04354
申请日期
2002.04.18
申请人
BIOFERMA MURCIA, S.A.;SANCHEZ-FERRER, ALVARO;LOPEZ-MAS, JOSE ANICETO;GARCIA-CARMONA, FRANCISCO
发明人
SANCHEZ-FERRER, ALVARO;LOPEZ-MAS, JOSE ANICETO;GARCIA-CARMONA, FRANCISCO