PYRIMIDINOXYALKYLPIPERAZINES AND THEIR THERAPEUTIC USE

摘要

Pyrimidinoxyalkylpiperazines of the formula (I) in which n represents an integer from 2 to 6, R1 represents H, C1-C6-alkyl or phenyl ( C1-C6)-alkyl in which the phenyl radical can be substituted by one or more substituents selected from C1-C6-alkyl and C1-C6-alkoxy, R2 represents H, C1-C4-alkyl, OH, C1-C6-alkoxy, NH2 or C1-C6-halogenoalkyl, R3 and R4, independently of each other, represent H, C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-halogenoalkyl, pyrrolyl or phenyl, which latter can be substituted by one or more substituents selected from C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy, OH, halogen or C1-C6-halogenoalkyl, phenyl, cyano or nitro. The compounds can be used for treating diseases which respond to modulation of the dopamine D3 receptor and are characterized by a high degree of bioavailability.