EUROTINONE AND DERIVATIVES THEREOF, METHOD FOR THE PRODUCTION AND USE OF THE SAME

摘要

The invention relates to novel compounds of general formula (I), wherein R(1 ), R(2), R(3), R(4) independently represent hydrogen or an alkyl radical. The compounds of formula (I) are inhibitors of KDR-kinase, having an anti- angiogenetic effect, and are suited for the prevention and/or treatment of malignant illnesses. The compounds of formula (I) can be obtained by fermenting the microorganism Eurotium echinalutum Delacroix (DSM 13872) or b y means of chemical derivatization of the compounds obtained after fermenting said microorganism. The invention also relates to a method for producing compounds of Formula (I), the use of said compounds for producing a drug for treating malignant illnesses and illnesses which can be treated by inhibitin g KDR-Kinase, and for pharmaceutical preparations containing at least one compound of formula (I).