MATRIX CONTROLLED TRANSDERMAL SYSTEM FOR STABILE DERIVATIVES OF ACE INHIBITORS

摘要

The invention relates to a matrix controlled transdermal therapeutic system comprising, (i) a top layer which is impervious to active ingredients, (ii) a self adhesive matrix layer or several matrix layers, whereby at least the exposed matrix layer is self adhesive when the system is applied, or comprising one or several matrix layers whose surface faces away from the to p layer and is provided for adhesion to the place of application, said surface being covered with an adhesive. The matrix layers contain at least one ACE inhibitor (angiotensin converting enzyme inhibitor). The metabolite thereof is a dicarboxylic acid selected from the following group: diesters, a di-salt which is obtainable with one or several bases and a mono-salt which is obtainable with one or several acids and (iii) a tear-off protective layer.< /SDOAB>