发明名称 |
BETA-HYDROXYAMINE DERIVATIVES USEFUL IN TREATMENT OF ALZHEIMER'S DISEASE |
摘要 |
The invention relates to substituted alcohol compounds of the formula (I), wherein X, R1, R2, R3, RN, R20 et RC are defined herein. The compounds are useful in the treatment or prevention of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptid e (A-beta), a major component of the amyloid plaques found in the brains of Alzhaimer's sufferers.
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申请公布号 |
CA2452039(A1) |
申请公布日期 |
2003.01.09 |
申请号 |
CA20022452039 |
申请日期 |
2002.06.27 |
申请人 |
ELAN PHARMACEUTICALS, INC.;PHARMACIA & UPJOHN COMPANY |
发明人 |
JOHN, VARGHESE;HOM, ROY;TUCKER, JOHN |
分类号 |
A61K31/4164;A61K31/4184;A61K31/4196;A61K31/519;A61P25/00;A61P25/16;A61P25/28;C07D233/84;C07D233/90;C07D235/28;C07D249/12;C07D409/04;C07D473/38;C07D487/04;(IPC1-7):C07D473/38;A61K31/416;A61K31/417;A61K31/418;A61K31/419;A61K31/52 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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