CYCLIC DIAMINE COMPOUNDS HAVING FUSED-RING GROUPS

摘要

Cyclic diamine compounds represented by the general formula (1), acid-additi on salts thereof, or hydrates of both, and medicines containing the compounds, salts or hydrates: (1) [wherein R1 and R2 are each hydrogen or methoxy, with the proviso that when R2 is hydrogen, R1 is methoxy, while when R2 is methox y, R1 is hydrogen; A is oxygen, sulfur, CH=CH, CH=N, or NR3 (wherein R3 is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, aryl, or aryl-lower alkyl); B is nitrogen, CH, or CR4 (wherein R4 is hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, aryl, or aryl-lower alkyl); m is a number of 1 or 2; and n is a number of 1 to 5]. The above compounds, salts and hydrates exhibit inhibitory activity against cell adhesion and are useful as drugs for allergy, asthma, rheumatic diseases, arteriosclerosis, inflammation, and so on.