发明名称 |
CONTROLLED RELEASE COMPOSITION AND METHOD OF PRODUCING THE SAME |
摘要 |
A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3. |
申请公布号 |
WO03002092(A2) |
申请公布日期 |
2003.01.09 |
申请号 |
WO2002JP06527 |
申请日期 |
2002.06.28 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;YAMAMOTO, KAZUMICHI;YAMADA, AKIKO;HATA, YOSHIO |
发明人 |
YAMAMOTO, KAZUMICHI;YAMADA, AKIKO;HATA, YOSHIO |
分类号 |
A61K47/12;A61K;A61K9/00;A61K9/107;A61K9/16;A61K9/22;A61K9/52;A61K38/00;A61K38/04;A61K38/09;A61K38/22;A61K38/24;A61K45/00;A61K47/34;A61P5/00;A61P5/06;A61P5/24;A61P13/08;A61P15/00;A61P15/08;A61P15/12;A61P15/18;A61P25/28;A61P35/00;A61P37/00;A61P37/04;A61P43/00;C07K7/23;C08K5/13;C08L67/04;C08L77/04;C08L101/16 |
主分类号 |
A61K47/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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