TILIANIN FOR ANTI-INFLAMMATORY ACTIVITY AND ANTI-ATHEROGENIC ACTIVITY

摘要

PURPOSE: Provided is tilianin for anti-inflammatory activity and anti-atherogenic activity, which inhibits expression of intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) and reduces progression of arteriosclerosis diseases. Therefore, it is useful for the prevention and treatment of cardiovascular diseases. CONSTITUTION: Tilianin is a synthetic chemical compound or isolated from Prunella vulgaris var. lilacina. It characteristically inhibits intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1), and is represented by the formula(1). The anti-inflammatory and anti-atherogenic agents contains the tilianin as an active ingredient.