发明名称 |
PROCESS FOR PRODUCING QUINOLINECARBALDEHYDE |
摘要 |
A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde of the formula (III): <CHEM> characterized by oxidizing 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline of the formula (I) : <CHEM> with a salt of a hypohalogenous acid in the presence of a quaternary ammonium salt of the formula (II): <CHEM> wherein each of R<1>, R<2>, R<3> and R<4> which are the same or different from one another, is a C1-16 alkyl group or a benzyl group (the benzyl group may be substituted by a C1-4 alkyl group, a C1-4 alkoxy group or a halogen atom), and X<-> is a halogen ion, a sulfate ion or a methanesufonate ion. |
申请公布号 |
EP1142876(A4) |
申请公布日期 |
2003.01.08 |
申请号 |
EP19990973606 |
申请日期 |
1999.11.29 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
MATSUMOTO, HIROO;SHIMIZU, TAKANORI;TAKADA, YASUTAKA |
分类号 |
C07D215/14 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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