High throughput identification of modulators of angiogenesis

摘要

The invention relates to the field of molecular genetics and medicine. In particular, the present invention relates to the field of functional genomics, more in particular to a method for the identification of genes that function in the formation of blood vessels. The present invention provides the methods and means for the identification of nucleic acids and the polypeptides encoded by these nucleic acids that have a function related to angiogenesis, which were isolated in a high-throughput screening assay using the in vitro capillary formation assay as a read-out. The identified compounds are suitable drug-targets to treat human diseases.