摘要 |
Quinazolines of formula (I) (in which R1 and r2 are H, alkyl, alkoxy, NO2, CF3 alkylthio, alkylsulphonyl or halogen, R3 is H, alkyl, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkenyl, naphthyl pyridyl, furyl, pyrrolyl, thienyl, imidazolyl, pyrazolyl, oxazolyl, thiazolyl, pyrimidinyl, indolyl, quinolyl, haloalkyl, alkylthioalkyl, alkoxycarbonylalkyl, alkanoyloxyalkyl, or -CnH2nNR4R5 or -CnH2n-CONR6R7 in which n is 1-4, R4 and Rk are alkyl and R6 and R7 are H or alkyl, or -NR4R5 or -NR6R7 may form a 5 or 6 membered heterocyclic ring which may be substd and may contain an additional heteroatom, and R is H, alkyl, alkenyl, aralkyl, alkoxyalkyl, cycloalkylalkyl, haloalkyl, trihalomethylalkyl, alkylthioalkyl, alkanoyloxyalkyl or -CnH2nNR4R5 or -CnH2nCONR6R7) are prepd by reacting a cpd of formula (II) (X = halogen) with NH3. (I) have antiinflammatory and analgesic activity. Cpds of formula (II) and of formula (I) when R is 3-6C cycloalkyl-1-4C alkyl are new. |