发明名称 |
Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII for binding cells |
摘要 |
Fibrin microbeads are prepared containing extensively cross-linked fibrin (ogen) without using glutaraldehyde. The fibrin microbeads are preferably prepared by containing an aqueous solution containing fibrinogen, thrombin and Factor XIII with an oil heated to about 50-80° C. to form an emulsion and mixing the emulsion at 50-80° C. until fibrin microbeads containing extensively cross-linked fibrin (ogen) are obtained. The fibrin microbeads may have a diameter of about 50-200 microns and can contain a bioactive agent. The fibrin microbeads are used for binding cells such as when culturing or separating one cell type from another, or when transplanting cells or engineering tissue.
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申请公布号 |
US6503731(B2) |
申请公布日期 |
2003.01.07 |
申请号 |
US19980153547 |
申请日期 |
1998.09.15 |
申请人 |
HADASIT MEDICAL RESEARCH & DEVELOPMENT LTD. |
发明人 |
MARX GERARD;GORODETSKY RAPHAEL |
分类号 |
C12N9/48;A61F2/00;A61K9/127;A61K9/16;A61K9/22;A61K9/26;A61K9/50;A61K35/12;A61K35/30;A61K35/407;A61K38/17;A61K38/43;A61L24/00;A61L26/00;A61L27/00;A61L27/22;A61L27/38;C07K14/745;C07K14/75;C12N5/00;C12N5/071;C12N5/077;C12P21/00;(IPC1-7):C12P21/06;C12N5/06;C12N7/02;C12N11/02;A61K35/14 |
主分类号 |
C12N9/48 |
代理机构 |
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地址 |
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