QUINAZOLINONE-CONTAINING PHARMACEUTICAL COMPOSITIONS FOR PREVENTION OF NEOVASCULARIZATION AND FOR TREATING HUMAN MALIGNANCIES

摘要

The invention provides a composition for attenuating neovasculatization and treating human malignancies, including a pharmaceutically effective amount of a compound of formula (I), wherein n = 1 or 2; R1 is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy; R2 is a member of the group consisting of hydroxy, acetoxy and lower alkoxy; and R3 is a member of the group consistin g of hydrogen and lower alkenoxy-carbonyl; as active ingredient therein, in combination with a pharmaceutically acceptable carrier and the physiologically acceptable salts thereof. (see formula I)