发明名称 PEDIATRIC FORMULATION OF GATIFLOXACIN
摘要 There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.
申请公布号 WO03000175(A2) 申请公布日期 2003.01.03
申请号 WO2002US14596 申请日期 2002.05.10
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 RAGHAVAN, KRISHNASWAMY, S.;RANADIVE, SUNANDA, A.;BEMBENEK, KENNETH, S.;BENKERROUR, LOUTFY;TROGNON, VERONIQUE;CORRAO, RICHARD, G.;ESPOSITO, LUIGI
分类号 C07D401/04;A61K31/445;A61K31/496;A61K47/12;A61P31/04;C07D215/56;C07D401/10 主分类号 C07D401/04
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