发明名称 |
CONJUGATES OF ANTIBODIES AND ANTICANCER DRUGS |
摘要 |
The present invention relates to a compound to selectively kill or protect a target cell in a patient with reduced systemic toxicity, which comprises a compound of the formula: W-Z-X wherein, X is a toxic agent or protective agent; W is a biologically active molecule which is adapted to selectively bind the target cell directly or indirectly; and Z is a breakable linker which covalently links W and X together, wherein the linked W remains bioavailable and bioactive, whereby the breakable linker releases the toxic agent or protective agent into the cell. |
申请公布号 |
WO0249672(A3) |
申请公布日期 |
2003.01.03 |
申请号 |
WO2001CA01854 |
申请日期 |
2001.12.21 |
申请人 |
MCGILL UNIVERSITY;SARAGOVI, H., URI;GUILLEMARD, VERONIQUE |
发明人 |
SARAGOVI, H., URI;GUILLEMARD, VERONIQUE |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|