OXA(THIA)ZOLIDINE COMPOUNDS,PROCESS FOR PREPARATION THEREOF AND ANTI−INFLAMMATORY AGENTS

摘要

Compounds represented by the general formula [I] or medicinally acceptable complexes thereof; and compositions containing the compounds or the complexes as the active ingredient: [I] [wherein X is oxygen or sulfur; R1 is C1−4 alkyl, optionally substituted phenyl, or the like; Q1 is a spacer group having 0 to 3 carbon atoms; R2 is optionally substituted phenyl or the like; R3 is hydrogen, C1−4 alkyl, −CONH−R6, or the like; and R4 and R5 are each nitro, cyano, C1−4 alkylcarbonyl, or the like]. The compounds and complexes and the compositions can relieve morbid symptoms accompanied with enhanced activity of phospholipase A(2) and are useful as remedies for inflammatory diseases and/or allergic diseases, or the like.