| 摘要 |
<p>Compounds represented by the following general formula(1),salts thereof,solvates of the same or N−oxides of the same:Q<sp>1</sp>−Q<sp>2</sp>−T<sp>0</sp>−N(R<sp>1</sp>)−Q<sp>3</sp>−N(R<sp>2</sp>)−T<sp>1</sp>−Q<sp>4</sp>(1)wherein R<sp>1</sp> and R<sp>2</sp> represent each hydrogen,etc.;Q<sp>1</sp> represents optionally substituted,saturated or unsaturated 5−or 6−membered hydrocarbyl,etc.;Q<sp>2</sp> represents a single bond,etc.;Q<sp>3</sp> represents the following group;(wherein Q<sp>5</sp> represents C<sb>1−8</sb> alkylene,etc.);and T<sp>0</sp> and T<sp>1</sp> represent each carbonyl,etc.These compounds are useful as preventives and/or remedies for brain infarction,cerebral embolism,myocardial infarction,angina,pulmonary infarction,pulmonary embolism,Buerger’s disease,bottom venous thrombosis,disseminated intravascular coagulation,thrombosis following artificial valve/joint replacement,thrombosis and reocclusion following circulation reconstruction,systemic inflammatory responsive syndrome(SIRS),multiple organ dysfunction(MODS),thrombosis in extracorporeal circulation or blood coagulation in collecting blood.</p> |
| 申请人 |
DAIICHI PHARMACEUTICAL CO., LTD.;OHTA, TOSHIHARU;KOMORIYA, SATOSHI;YOSHINO, TOSHIHARU;UOTO, KOUICHI;NAKAMOTO, YUMI;NAITO, HIROYUKI;MOCHIZUKI, AKIYOSHI;NAGATA, TSUTOMU;KANNO, HIDEYUKI;HAGINOYA, NORIYASU;YOSHIKAWA, KENJI;NAGAMOCHI, MASATOSHI;KOBAYASHI, SYOZO;ONO, MAKOTO |
发明人 |
OHTA, TOSHIHARU;KOMORIYA, SATOSHI;YOSHINO, TOSHIHARU;UOTO, KOUICHI;NAKAMOTO, YUMI;NAITO, HIROYUKI;MOCHIZUKI, AKIYOSHI;NAGATA, TSUTOMU;KANNO, HIDEYUKI;HAGINOYA, NORIYASU;YOSHIKAWA, KENJI;NAGAMOCHI, MASATOSHI;KOBAYASHI, SYOZO;ONO, MAKOTO |
