CRYSTAL STRUCTURE OF THE APC10/DOC1 SUBUNIT OF THE HUMAN ANAPHASE-PROMOTING COMPLEX

摘要

The invention relates to the crystal structure of APC10/DOC1, a subunit of human anaphase-promoting complex (APC), the use of a crystalline APC10/COC1 subunit in order to obtain crystal structure data enabling rational drug design and screening for inhibitors of APC, pharmaceutical compositions containing such inhibitors as well as the use of inhibitors to prevent the induction of anaphase.