PROTEIN AGGREGATION ASSAYS AND USES THEREOF

摘要

This invention features methods for identifying agents that modulate protein aggregation or stabilize protein conformation. Exemplary methods include an in vitro aggregation assay, a native state stabilization assay, a cell-based screening assay, and an animal-based screening assay. These methods can be used to identify agents useful for the treatment of conformational diseases resulting from aggregation of a protein.