A TGF−ß superfamily production/secretion promoter containing a compound which is represented by the formula (I) (wherein R<sp>1</sp> represents halogeno, an optionally substituted heterocyclic group, optionally substituted hydroxy, optionally substituted thiol, or optionally substituted amino; A represents optionally substituted acyl, an optionally substituted heterocyclic group, optionally substituted hydroxy, or optionally esterified or amidated carboxyl; B represents an optionally substituted aromatic group; X represents oxygen, sulfur, or optionally substituted nitrogen; and Y represents a divalent hydrocarbon group or heterocyclic group) or containing a salt or prodrug of the compound. The promoter is useful as a preventive/remedy for autonomic neuropathy, bladder function disorders, auditory disorders, bone diseases, etc.
申请公布号
WO03000257(A1)
申请公布日期
2003.01.03
申请号
WO2002JP06350
申请日期
2002.06.25
申请人
TAKEDA CHEMICAL INDUSTRIES, LTD.;SUGIYAMA, YASUO;HAZAMA, MASATOSHI;SHINTANI, ASAE