USE OF NA+ CHANNEL BLOCKERS AND ASPIRIN IN MANUFACTURING DRUGS FOR PRODUCING ANALGESIA SYNERGISTICALLY IN MAMMALS

摘要

The present invention relates to the use of combinations of sodium channel blocking compounds and aspirin in manufacturing drugs for producing synergistically analgesic effect in mammals, in which said compounds bind to .alpha.-subunit of SS1 or SS2 sites in the sodium channel. According to the invention, pharmaceutical compositions have enhancing analgesic effect, and therefore dosage of aspirin as well as its side effects would be reduced.