NUCLEOSIDE COMPOUNDS IN HCV

摘要

Protide compounds of formula (I) wherein X represents H, F, N3, NH2, -CN, or -OMe; X<l> represents 0 or NR<7>; X<2> represents O, NH, NR<6> or S, or when X<3> is O then X<2> is absent; X<3> is absent, or when X<1> is O then X<3> represents O; R<1> represents hydrogen; optionally substituted C1-6alkyl; optionally substituted aryl; or optionally substituted heteroaryl; R<2> represents hydroxy, OCOR<6>, or OCO2R<6>; R<3> represents H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R<4> and R<5> are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted aralkyl; R<6> represents optionally substituted C1-6alkyl or optionally substituted aryl; R<7> represents H, optionally substituted C1-6alkyl, or optionally substituted aryl, wherein when R<4> and R<7> are each alkyl they may be linked to form a 5- or 6-membered ring; B represents (a), (b), (c), or (d) wherein Z represents O or S; R<8> represents H, halo, C2-4alkynyl, trifluoromethyl, Cl-3alkoxy, hydroxy, methylthio, amino, nitro, or C1-3alkyl wherein the Cl-3alkyl may be optionally substituted by hydroxy, halo, amino, or OR<10> wherein R<10> represents C1-6alkyl optionally substituted by aryl which may itself be optionally substituted; and R<9> represents H, halo, hydroxy, OR<6>, SR<6> or NR<3>R<3>; are useful in the treatment of viral infection, particularly HCV infection.