TRANSGENIC ANIMALS AND CELLS EXPRESSING PROTEINS NECESSARY FOR SUSCEPTIBILITY TO HIV INFECTION

摘要

The present invention provides mammalian cells and mammalian animals that produce HIV particles. The rodent animals of the present invention are able to stably express a human CD4, a human chemokine receptor (such as CXCR4 or CCR5), a human cyclin T1, and a human class II transactivator (CIITA), and produce HIV virus particles. Also provided are methods of preparing the transgenic cells and rodent animals of the invention, as well as methods of using them to identify and assay test agents for anti-HIV activity. Also provided are methods and pharmaceutical compositions for treating and preventing HIV infection in a mammal.