DEVICE FOR SIMULTANEOUS MULTIPLE AND HIGH PARALLEL SYNTHESIS

摘要

The invention relates to a device for simultaneous multiple and high parallel synthesis of compounds based on solid phase synthesis, especially for peptide synthesis. In order to avoid multiple, time-consuming and costly rinsing processes which were previously necessary for solid phase synthesis after the distribution and replacement of reagents, an improved device is provided for fully automated synthesis and subsequent decomposition of the synthesized compounds, wherein respectively separate synthesis pins (11) are provided for the synthesis building blocks and provided with a reagent reservoir (20;21) and individual dosing. The synthesis pins (11) are disposed in a separate holder (4) and are taken from said holder (4) by a gripping arm (2) of the synthesis machine (1). The reaction chambers (9) of the synthesis plates (5) are sealed (covered) on the open sides thereof by a permeable material (25) to ensure that the synthesis pins (11) are placed and that the reagents are dosed in a contamination-free manner on the solid or liquid phase. A sample plate (27) is arranged underneath the valve block (6) in order to receive the samples which are released after the decomposition reaction.