Ointments containing a chemically modified physiologically active polypeptide (wherein the chemically modified physiologically active polypeptide is exemplified by a physiologically active polypeptide chemically modified with at least one polyalkylene glycol and the physiologically active polypeptide to be chemically modified is exemplified by superoxide dismmutase, interferon−&agr;, interferon−&bgr;, interferon−ϝ and granulocyte colony−stimulating factor).