发明名称 |
Process for producing stereoisomer of pyrrolidine derivative |
摘要 |
The present invention provides a process for producing optically active 3-hydroxy-4-methoxypyrrolidine, which is an intermediate for synthesizing a quinuclidine derivative useful as a squalene synthetase inhibitor, a salt thereof, or a hydrate thereof by subjecting a pyrrolidine derivative represented by the following formula (1-4): wherein R3a and R3b are different and each of R3a and R3b represents a hydrogen atom or a methyl group, to optical division purification by using an optically active dibenzoyltartaric acid derivative or the like.
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申请公布号 |
US2003004208(A1) |
申请公布日期 |
2003.01.02 |
申请号 |
US20020142339 |
申请日期 |
2002.05.08 |
申请人 |
HAGA TOYOKAZU;KAYANO AKIO;SASYOU MANABU;NEGI SHIGETO;NAKA HIROYUKI;NODA HIROFUMI;SAKAI KEN-ICHI |
发明人 |
HAGA TOYOKAZU;KAYANO AKIO;SASYOU MANABU;NEGI SHIGETO;NAKA HIROYUKI;NODA HIROFUMI;SAKAI KEN-ICHI |
分类号 |
C07D207/12;C07D401/04;C07D453/02;C07D491/04;(IPC1-7):A61K31/401 |
主分类号 |
C07D207/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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