BIOKOMPATIBLE HYDROPHILE GLEITMITTEL FUR MEDIZINISCHE INSTRUMENTE

摘要

A biocompatible, lubricious, hydrophilic material useful for coating medical devices or for blending into polymer compositions intended for making medical devices comprises a terpolymer of 5 to 25 mole percent of a polymerisable monomer (1) having a polyethylene oxide unit with an average degree of polymerisation from 5 to 18 and a polymerisable carbon-carbon double bond, 5 to 30 mole percent of a polymerisable monomer (2) having a polyethylene oxide unit with an average degree of polymerisation from 19 to 65 and polymerisable carbon-carbon double bond, and 45 to 90 mole percent of an alkyl methacrylate (3): (1) CH2=C(R)-CO-[-O-CH2-CH2-]n1-O-R where n1 is from 5 to 18, and each R is independently H or CH3; (2) CH2=C(R)-CO-[-O-CH2-CH2-]n2-O-R where n2 is from 19 to 65 and each R is independently H or CH3; (3) CH2=C(CH3)-CO2-(CH2)m-CH3 where m is from 3 to 17, which may be made by the aqueous emulsion polymerisation of the monomers.