| 摘要 |
The invention relates to indirubin derivatives of formula (I) that, by establishing a basic side chain in the 5-position, contain a radically increased solubility with a simultaneous improvement in the biological activity. The invention also relates to intermediate products, to a method for the production thereof, and to their use as Cdk inhibitors for treating cancer such as solid tumors and leukemia, autoimmune diseases such as psoriasis, alopecia and multiple sclerosis, chemotherapeutic agent-induced alopecia and mucositis, cardiovascular diseases such as stenoses, arterioscleroses, restenoses, infectious diseases, e.g. those caused by unicellular parasites, such as Trypanosoma, Toxoplasma or Plasmodium, or caused by fungi, nephrological diseases, e.g. glomerulonephritis, chronic neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, AIDS dementia and Alzheimer's disease, acute neurodegenerative diseases such as ischemias of the brain and neurotrauma, viral infections such as cytomegalic infections, herpes, hepatitis B and C, and HIV diseases.
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