发明名称 |
IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases |
摘要 |
The invention provides therapeutic and biological uses of chemokine-receptor-binding compounds (including chemokine receptor ligands such as chemokine receptor agonists or antagonists), such as benzopyrone derivatives, including uses in the treatment of disease states mediated by chemokines. The relevant chemokine may for example be interleukin-8 (IL-8), and the relevant chemokine receptors may for example be corresponding chemokine receptors (CXCR-1 and/or CXCR-2). In other aspects, the invention provides corresponding pharamaceutical compositions and therapeutic methods. In one aspect, for example, the invention provides for the use of [7-[benzopyrone-5'(3'-amino)-thiazole]-phenylalanine-benyl ester in the treatment of disease.
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申请公布号 |
US2003004136(A1) |
申请公布日期 |
2003.01.02 |
申请号 |
US20010992541 |
申请日期 |
2001.11.13 |
申请人 |
SAXENA GEETA;TUDAN CHRISTOPHER R.;CHENG N. NICK;SALARI HASSAN |
发明人 |
SAXENA GEETA;TUDAN CHRISTOPHER R.;CHENG N. NICK;SALARI HASSAN |
分类号 |
A61K31/35;A61K31/352;A61K31/353;A61K31/38;A61K31/4178;A61K31/427;A61K31/665;A61K31/67;A61K31/695;A61P29/00;A61P35/00;A61P37/00;C07D277/30;(IPC1-7):A61K31/695;A61K31/675;A61K31/47 |
主分类号 |
A61K31/35 |
代理机构 |
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代理人 |
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地址 |
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