发明名称 |
In vivo selection of primitive hematopoietic cells |
摘要 |
The invention is directed to a method of in vivo selection for genetically modified hematopoietic progenitor cells from nonmodified hematopoietic cells in a subject. Ibis goal is accomplished by introducing mutant dihydrofolate reductase genes into hematopoietic progenitor cells and then administering to a subject harboring the resultant transformed cells an antifolate and a nucleoside transport inhibitor. The invention is also directed to nucleic acids encoding mutant dihydrofolate reductase genes and to hematopoietic cells transformed with such mutant genes.
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申请公布号 |
US6500421(B1) |
申请公布日期 |
2002.12.31 |
申请号 |
US19990297749 |
申请日期 |
1999.05.04 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
SORRENTINO BRIAN P.;BLAKELY RAYMOND L.;ALLAY JAMES;SPENCER H. TRENT |
分类号 |
A61K35/14;A61K48/00;(IPC1-7):A01N63/00;C12N15/00;C12N5/00;C12N15/86 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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