| 发明名称 |
ENANTIOSELECTIVE SYNTHESIS OF 5,6-DIHYDRO-(S)-4-(ETHYLAMINO)-(S)-6- METHYL-4H-TIENO /2,3-B/ THIOPYRAN-2-SULFONAMIDE 7,7-DIOXIDE AND RELATED COMPOUNDS |
| 摘要 |
<p>A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran- 2-sulfonamide 7,7-dioxide (dorzolamide) and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.</p> |
| 申请公布号 |
SI9420016(B) |
申请公布日期 |
2002.12.31 |
| 申请号 |
SI19940020016 |
申请日期 |
1994.03.16 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
SOHAR PAUL;MATHRE DAVID J.;BLACKLOCK THOMAS J. |
| 分类号 |
A61K31/38;A61P27/02;A61P43/00;C07D495/04;(IPC1-7):C07D495/04;C07D335/00;C07D333/00 |
主分类号 |
A61K31/38 |
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