| 摘要 |
PURPOSE: A medicament which is effective for a virus with drug-resistant mutation is provided, thereby supplying an important antiviral agent for the treatment of hepatitis B and human immunodeficiency syndrome. CONSTITUTION: A medicament which is effective for a virus with drug-resistant mutation is a phosphate nucleotide compound represented by formula(I), wherein R1 is hydrogen, C1-C6 alkoxy, one or more halogen substituted C1-C4 alkoxy, halogen, amino, hydroxy or nitro; R2 and R3 are independently hydrogen, C1-C22 alkyl, acyloxymethyl, acylthioethyl, or one or more halogen substituted ethyl; R4 is hydrogen, C1-C4 alkyl, C1-C4 hydroxyalkyl or one or more halogen substituted C1-C4 alkyl; and X is CH or nitrogen, salts thereof, or hydrate or solvate thereof.
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