发明名称 |
Method for identifying an unknown allele |
摘要 |
The invention provides a method for identifying an unknown allele of a polyallelic gene, which method comprises (i) contacting the unknown allele with a panel of probes, each of which recognises a sequence motif that is present in some alleles of the polyallelic gene but not in others; (ii) observing which probes recognise the unknown allele so as to obtain a fingerprint of the unknown allele; and (iii) comparing the fingerprint with fingerprints of known alleles. The use of a panel of probes which each recognises a different motif allows identification of which motifs are present in the unknown allele. The alleles of the polyallelic gene each have a unique combination of motifs and so identification of this combination (or "fingerprint") leads to identification of the unknown allele.
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申请公布号 |
US6500614(B1) |
申请公布日期 |
2002.12.31 |
申请号 |
US20000077619 |
申请日期 |
2000.03.31 |
申请人 |
THE ANTHONY NOLAN BONE MARROW TRUST |
发明人 |
ARGUELLO RAFAEL;AVAKIAN HOVANES;MADRIGAL ALEJANDRO |
分类号 |
C12Q1/68;(IPC1-7):C12Q1/68;C12P19/34;C07H21/02;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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主权项 |
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地址 |
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