ANALOGS OF KERATINOCYTE GROWTH FACTOR HAVING ENHANCED TEMPERATURE STABILITY

摘要

Analogs of proteins in the FGF family are provided in accordance with the pr esent invention. These analogs are more stable than the corresponding naturally occurring proteins. Enhanced stability may be ac hieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in an identified loop-forming region in the a mino acid sequence of the protein. The analogs of the present invention are espec ially useful in therapeutic applications.