发明名称 |
EGLIN C BASED DRUGS FOR TREATMENT OF DISEASE |
摘要 |
The present invention relates to eglin c variants which inhibit proteases, and in particular to eglin c mutants at adventitious c ontact sites. The present invention also relates to eglin c variants which comprise mutations in both adventitious contact sites and at reactive loop sites. The present invention further relates to methods of preparing the eglin c variants, and methods of using the eglin c variants for treatment of diseases including acute bacterial, viral, and fungal infections. |
申请公布号 |
WO02102318(A2) |
申请公布日期 |
2002.12.27 |
申请号 |
WO2002US19394 |
申请日期 |
2002.06.18 |
申请人 |
REGENTS OF THE UNIVERSITY OF MICHIGAN;KOMIYAMA, TOMOKO;FULLER, ROBERT, S. |
发明人 |
KOMIYAMA, TOMOKO;FULLER, ROBERT, S. |
分类号 |
A61K38/00;A61K38/54;A61K38/58;C07H21/02;C07K14/815;C12N1/12;C12N15/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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